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Epalrestat

SIGMA/SML0527 - ≥98% (HPLC)

Synonym: (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

CAS Number: 82159-09-9
Empirical Formula (Hill Notation): C15H13NO3S2
Molecular Weight: 319.40
Linear Formula: C15H13NO3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0527-10MG 10 mg
 $132.00
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45-SML0527-50MG 50 mg
 $510.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color yellow to orange
form powder
InChI 1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChI key CHNUOJQWGUIOLD-NFZZJPOKSA-N
Quality Level 100 
SMILES string S1C(=C/C(=C/c2ccccc2)/C)C(=O)N(C1=S)CC(=O)O
solubility DMSO: 5 mg/mL, clear (warmed)
storage condition protect from light
storage temp. −20°C
Application: Epalrestat has been used as an aldose reductase inhibitor:
• in the dahomey larvae diet fed forDrosophila
• for non-irradiated and X-ray irradiated human aldose reductase
• to test its protective effect in mice with bleomycin-induced pulmonary fibrosis
Biochem/physiol Actions: Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.
Biochem/physiol Actions: Epalrestat is an Aldose Reductase inhibitor.
Features and Benefits: This compound is featured on the Dopamine and Norepinephrine Metabolism  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes: Light sensitve
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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