BIM5078

SIGMA/SML0528 - ≥98% (HPLC)

Synonym: 1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole; 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole

CAS Number: 337506-43-1
Empirical Formula (Hill Notation): C₁₄H₁₀ClN₃O₄S
Molecular Weight: 351.76
MDL Number: MFCD01173148
Linear Formula: C₁₄H₁₀ClN₃O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0528-5MG	5 mg	$154.00 1/EA	Add To Favorites
45-SML0528-25MG	25 mg	$591.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C14H10ClN3O4S/c1-9-16-12-4-2-3-5-13(12)17(9)23(21,22)14-8-10(18(19)20)6-7-11(14)15/h2-8H,1H3
InChI key	DLUVMRPVZILBOE-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC1=NC2=CC=CC=C2N1S(C3=C(Cl)C=CC([N+]([O-])=O)=C3)(=O)=O
solubility	DMSO: 10 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	BIM5078 is a potent Hepatocyte nuclear factor 4α antagonist.
Biochem/physiol Actions:	BIM5078 is a potent Hepatocyte nuclear factor 4a (HNF4a) antagonist that directly binds to ligand-binding pocket and modulates the expression of known HNF4a target genes. BIM5078 also inhibits insulin gene expression by disruption of E47 and PDX-1 binding to insulin promoter. BIM5078 is selectively cytotoxic to transformed cells.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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