Synonym: (2′Z,3′E)-6-Bromoindirubin-3′-acetoxime; (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one; 6-Bromoindirubin acetoxime; 6-Bromoindirubin-3′-acetoxime; BIA
CAS Number: 667463-85-6
Empirical Formula (Hill Notation): C18H12BrN3O3
Molecular Weight: 398.21
MDL Number: MFCD09037533
Linear Formula: C18H12BrN3O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
, dark red to purple |
| form |
powder |
| InChI |
1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+ |
| InChI key |
MENDIXKFTXYTHJ-HPBPSMLHSA-N |
| Quality Level |
100  |
| SMILES string |
CC(=O)ON=C1C(Nc2ccccc12)=C3C(=O)Nc4cc(Br)ccc34 |
| solubility |
H2O: 2 mg/mL (clear solution, warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation. |
| Biochem/physiol Actions: |
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor. |
| Features and Benefits: |
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
GHS07,GHS09