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BIO-Acetoxime

SIGMA/SML0531 - ≥98% (HPLC)

Synonym: (2′Z,3′E)-6-Bromoindirubin-3′-acetoxime; (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one; 6-Bromoindirubin acetoxime; 6-Bromoindirubin-3′-acetoxime; BIA

CAS Number: 667463-85-6
Empirical Formula (Hill Notation): C18H12BrN3O3
Molecular Weight: 398.21
MDL Number: MFCD09037533
Linear Formula: C18H12BrN3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0531-5MG 5 mg
 $189.00
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45-SML0531-25MG 25 mg
 $723.00
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This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0531-25MG.

 

assay ≥98% (HPLC)
color , dark red to purple
form powder
InChI 1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+
InChI key MENDIXKFTXYTHJ-HPBPSMLHSA-N
Quality Level 100 
SMILES string CC(=O)ON=C1C(Nc2ccccc12)=C3C(=O)Nc4cc(Br)ccc34
solubility H2O: 2 mg/mL (clear solution, warmed)
storage temp. 2-8°C
Biochem/physiol Actions: BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Biochem/physiol Actions: BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor.
Features and Benefits: This compound is featured on the GSK-3  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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