Sufentanil citrate

SIGMA/SML0535 - ≥98% (HPLC)

Synonym: N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide citrate; R-33800; Sufentanyl citrate

CAS Number: 60561-17-3
Empirical Formula (Hill Notation): C₂₂H₃₀N₂O₂S · C₆H₈O₇
Molecular Weight: 578.67
EC Number: 262-295-4
Linear Formula: C₂₂H₃₀N₂O₂S · C₆H₈O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0535-5MG	5 mg	$251.00 1/EA	Add To Favorites
45-SML0535-25MG	25 mg	$680.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
drug control	kontrollierte Droge in Deutschland
	USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
form	powder
InChI	1S/C22H30N2O2S.C6H8O7/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-10,17H,3,11-16,18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key	OJCZPLDERGDQRJ-UHFFFAOYSA-N
Quality Level	100
SMILES string	[s]1c(ccc1)CCN2CCC(CC2)(N(c3ccccc3)C(=O)CC)COC.OC(CC(=O)O)(CC(=O)O)C(=O)O
solubility	H₂O: 1 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Biochem/physiol Actions:	Sufentanil is a mu-opioid receptor agonist; analgesic; anesthesia adjunct.
Biochem/physiol Actions:	Sufentanil is a mu-opioid selective agonist, 10 times more potent than fentanyl, over 1000 times more potent than morphine. Sufentanil citrate is used as an analgesic and anesthesia adjunct. There are some differences in activity and selectivity among the mu-opiate agonist analgesics. Receptor-internalizing agonists like beta-endorphin, methadone, fentanyl, and sufentanil have been found to induce NADH/NADPH-mediated reactive oxygen species (ROS) synthesis via Phospholipase D-dependent signaling pathways whereas agonists like morphine that do not induce receptor endocytosis failed to activate ROS synthesis. In another report meperidine, remifentanil and tramadol were found to interact with alpha(2)-adrenoceptors, whereas sufentanil did not.
Legal Information:	German Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG. English This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 + H310 + H330
Precautionary statements	P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	26-27-28-36/37/39
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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