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T863

SIGMA/SML0539 - ≥98% (HPLC)

Synonym: 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid; T-863; trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid

CAS Number: 701232-20-4
Empirical Formula (Hill Notation): C22H26N4O3
Molecular Weight: 394.47
MDL Number: MFCD11977270
Linear Formula: C22H26N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0539-5MG 5 mg
 $156.00
1/EA		 Add To Favorites
45-SML0539-25MG 25 mg
 $614.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI key FUIYMYNYUHVDPT-HDJSIYSDSA-N
Quality Level 100 
SMILES string CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
solubility DMSO: 15 mg/mL (clear solution)
storage temp. 2-8°C
Application: T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:
• to provide the opportunity to precisely control the DGAT inhibition
• to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
• to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
• to block lipid droplet (LD) formation
Biochem/physiol Actions: T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
Biochem/physiol Actions: T863 is an orally active, selective and potent DGAT1 inhibitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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