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Oxyphenbutazone

SIGMA/SML0540 - ≥98% (HPLC)

Synonym: 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione; G 27202; NSC 526053; Ro 04-4410; p-Hydroxyphenylbutazone; p-Oxyphenylbutazone

CAS Number: 129-20-4
Empirical Formula (Hill Notation): C19H20N2O3
Molecular Weight: 324.37
Linear Formula: C19H20N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0540-10MG 10 mg
 $156.00
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45-SML0540-50MG 50 mg
 $476.00
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assay ≥98% (HPLC)
color white to brown
form powder
InChI 1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
InChI key HFHZKZSRXITVMK-UHFFFAOYSA-N
Quality Level 100 
SMILES string N2(N(C(=O)C(C2=O)CCCC)c3ccccc3)c1ccc(cc1)O
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent.
Biochem/physiol Actions: Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent. Oxyphenbutazone is known to cause inflammatory effects on tissues. Oxyphenbutazone, as a drug, decreases cellular exudates, without involving the pituitary-adrenal axis or the immunity response. Though the drug delivers a number of side effects, it is considered to be less toxic than phenylbutazone, due to decreased rate of intestinal absorption.
Biochem/physiol Actions: Oxyphenbutazone is an NSAID that has been shown to preferentially kill non-replicating Mycobaterium tuberculosis maintained in media that simulates the mildly acidic, in vivo conditions where drug-resistant, non replicating subpopulations of the bacteria reside in hosts. The compound has little or no affect on replication M. tuberculosis grown in normal liquid cultures.
General description: Oxyphenbutazone is a derivative compound of phenylbutazone.
Other Notes: Air sensitive
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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