p38 MAP Kinase Inhibitor IV
SIGMA/SML0543 - ≥98% (HPLC)
Synonym: 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol); B10; MT4
CAS Number: 1638-41-1
Empirical Formula (Hill Notation): C12H4Cl6O4S
Molecular Weight: 456.94
Linear Formula: C12H4Cl6O4S
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C12H4Cl6O4S/c13-3-1-5( |
| InChI key | AKUKHICVNCCQHN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [S](=O)(=O)(c2c(c(cc(c2O) |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling. |
| Biochem/physiol Actions: | p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells. |
| Biochem/physiol Actions: | p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK. |
| Features and Benefits: | This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |