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JTV-519 hemifumarate

SIGMA/SML0549 - ≥98% (HPLC)

Synonym: 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate; K201 hemifumarate

CAS Number: 145903-06-6 (free base)
Empirical Formula (Hill Notation): C25H32N2O2S · .5C4H4O4
Molecular Weight: 482.63
MDL Number: MFCD23098915
Linear Formula: C25H32N2O2S · .5C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0549-5MG 5 mg
 $121.00
1/EA		 Add To Favorites
45-SML0549-25MG 25 mg
 $465.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/2C25H32N2O2S.C4H4O4/c2*1-29-23-7-8-24-22(18-23)19-27(15-16-30-24)25(28)11-14-26-12-9-21(10-13-26)17-20-5-3-2-4-6-20;5-3(6)1-2-4(7)8/h2*2-8,18,21H,9-17,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChI key MNAIJOCDPCXVEY-WXXKFALUSA-N
Quality Level 100 
SMILES string OC(=O)C=CC(O)=O.COc1ccc2SCCN(Cc2c1)C(=O)CCN3CCC(CC3)Cc4ccccc4.COc5ccc6SCCN(Cc6c5)C(=O)CCN7CCC(CC7)Cc8ccccc8
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: JTV-519 is a potent inhibitor or the ryanodine receptor 2 (RYR2) blocker. RYR2 is a cardiac calcium channel that regulates calcium levels in the sarcoplasmic reticulum. JTV-519 stabilizes RYR2 in the closed state.
Biochem/physiol Actions: JTV-519 is a RYR2 antagonist.
Features and Benefits: This compound is featured on the InsP3/Ryanodine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H410
Precautionary statements P273 - P501
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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