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Icaritin

SIGMA/SML0551 - ≥98% (HPLC)

Synonym: 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

CAS Number: 118525-40-9
Empirical Formula (Hill Notation): C21H20O6
Molecular Weight: 368.38
MDL Number: MFCD22422519
Linear Formula: C21H20O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0551-5MG 5 mg
 $136.00
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45-SML0551-25MG 25 mg
 $546.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color light yellow to dark yellow
form powder
InChI 1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
InChI key TUUXBSASAQJECY-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)c(CC=C(C)C)c3O2
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Icaritin enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs.
Biochem/physiol Actions: Icaritin enhances osteoblastic differentiation of mesenchymal stem cells (MSCs). It may have estrogen-like activities.
Biochem/physiol Actions: Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway. Icaritin has no effect on MSCs proliferation. Also, icaritin potently inhibits chronic myeloid leukemia (CML) and breast cancer cells proliferation most likely by modulation of MAPK/ERK/JNK and JAK2/STAT3 /AKT signaling. As other flavonoids, icaritin may exert estrogen-like activities.
Features and Benefits: This compound is featured on the JAKs , MAPKs  and Nuclear Receptors (PPARs)  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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