Tirapazamine
SIGMA/SML0552 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 27314-97-2
Empirical Formula (Hill Notation): C7H6N4O2
Molecular Weight: 178.15
MDL Number: MFCD00132954
Linear Formula: C7H6N4O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | , orange to dark orange-red |
| form | powder |
| InChI | 1S/C7H6N4O2/c8-7-9-11(13) |
| InChI key | ORYDPOVDJJZGHQ-UHFFFAOYSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | Nc1n[n+]([O-])c2ccccc2[n+ |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Tirapazamine has been used to evaluate its cytotoxic effect on U-251 MG (glioblastoma cell line) cell viability. |
| Biochem/physiol Actions: | Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin. |
| Biochem/physiol Actions: | Under hypoxic conditions, tirapazamine is a potent cytotoxic agent.. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352116 |