Synonym: 6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide; Tifenazoxide
CAS Number: 279215-43-9
Empirical Formula (Hill Notation): C9H10ClN3O2S2
Molecular Weight: 291.78
MDL Number: MFCD18711369
Linear Formula: C9H10ClN3O2S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) |
| InChI key |
KYSFUHHFTIGRJN-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC1(CC1)NC2=NS(=O)(=O)c3sc(Cl)cc3N2 |
| solubility |
DMSO: 15 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. |
| Biochem/physiol Actions: |
NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found that NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinson′s disease. |
| Features and Benefits: |
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
