NN414
SIGMA/SML0553 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 279215-43-9
Empirical Formula (Hill Notation): C9H10ClN3O2S2
Molecular Weight: 291.78
MDL Number: MFCD18711369
Linear Formula: C9H10ClN3O2S2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0553-25MG.
This image depicts SML0553-25MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C9H10ClN3O2S2/c1-9(2-3 |
| InChI key | KYSFUHHFTIGRJN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC1(CC1)NC2=NS(=O)(=O)c3s |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. |
| Biochem/physiol Actions: | NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found that NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinson′s disease. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |