SC-514
SIGMA/SML0557 - ≥97% (HPLC)
Synonym: 4-
CAS Number: 354812-17-2
Empirical Formula (Hill Notation): C9H8N2OS2
Molecular Weight: 224.30
Linear Formula: C9H8N2OS2
Product Type: Chemical
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| assay | ≥97% (HPLC) |
| color | white to light brown |
| form | powder |
| InChI | 1S/C9H8N2OS2/c10-6-3-7(5- |
| InChI key | BMUACLADCKCNKZ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [s]1c(cc(c1C(=O)N)N)c2c[s |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | SC-514 has been used to study its effect on lipopolysaccharide (LPS)-induced phosphorylation of NF-κB (nuclear factor-κB) p65 and p38 MAPK (mitogen-activated protein kinase). |
| Biochem/physiol Actions: | SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) that specifically blocks NF-?B-dependent gene expression. SC-514 exhibits anti-inflammatory properties. |
| Biochem/physiol Actions: | SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2). |
| Biochem/physiol Actions: | SC-514 is an amino-acetamide compound. It is selective for IKKβ with an IC50 value of 3−12 μM. SC-514 also inhibits cytokines such as interleukin-6 (IL-6) and IL-8, mediated by IKKβ. IKKβ is responsible for osteoclast survival, hence its inhibition affects osteogenesis. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |