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BRACO19 hydrochloride

SIGMA/SML0560 - ≥96% (HPLC)

Synonym: N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride

CAS Number: 1177798-88-7
Empirical Formula (Hill Notation): C35H43N7O2 · xHCl
Molecular Weight: 593.76 (free base basis)
MDL Number: MFCD23380200
Linear Formula: C35H43N7O2 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0560-5MG 5 mg
 $176.00
1/EA		 Add To Favorites
45-SML0560-25MG 25 mg
 $707.00
1/EA		 Add To Favorites

 

assay ≥96% (HPLC)
color yellow to brown
form powder
InChI 1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
InChI key MJAPNWJRLLDPAB-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
solubility H2O: 5 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).
Biochem/physiol Actions: BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
Biochem/physiol Actions: BRACO19 stabilizes G-quadruplexes; telomerase inhibitor.
Biochem/physiol Actions: Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P330 + P331 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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