3-AP

SIGMA/SML0568 - ≥98% (HPLC)

Synonym: 3-AP; 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone; PAN-811

CAS Number: 143621-35-6
Empirical Formula (Hill Notation): C₇H₉N₅S
Molecular Weight: 195.24
Linear Formula: C₇H₉N₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0568-5MG	5 mg	$102.00 1/EA	Add To Favorites
45-SML0568-25MG	25 mg	$410.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
InChI key	XMYKNCNAZKMVQN-NYYWCZLTSA-N
Quality Level	100
SMILES string	S=C(NN=Cc1ncccc1N)N
solubility	DMSO: 10 meq/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC₅₀ value of 0.3μM. It exhibits anti-proliferative activity in preclinical models of cancer, such as lung cancer. It also has an ability to increase the cytotoxicity, intracellular uptake and DNA incorporation of gemcitabine in vitro.
Biochem/physiol Actions:	3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.
Biochem/physiol Actions:	3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H315 - H319 - H335
Precautionary statements	P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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