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RO-3306

SIGMA/SML0569 - ≥98% (HPLC)

Synonym: (5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one; 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

CAS Number: 872573-93-8
Empirical Formula (Hill Notation): C18H13N3OS2
Molecular Weight: 351.45
MDL Number: MFCD17392573
Linear Formula: C18H13N3OS2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0569-5MG 5 mg
 $156.00
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45-SML0569-25MG 25 mg
 $645.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0569-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0569-5MG

 

assay ≥98% (HPLC)
color off-white to brown
form powder
InChI 1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChI key XOLMRFUGOINFDQ-YBEGLDIGSA-N
Quality Level 100 
SMILES string O=C1N=C(NCC2=CC=CS2)S/C1=CC3=CC4=C(C=C3)N=CC=C4
solubility DMSO: 5 mg/mL, clear
storage temp. 2-8°C
Application: RO-3306 has been used:
• To study the significance of CA4-mediated cytotoxicity in mitotic arrest
• In cell cycle synchronization to conduct a study on proteomics
• As a CDK1 inhibitor, to prevent early mitotic entry
Biochem/physiol Actions: CDK1 (cyclin dependent kinase 1) is considered to be the “master switch” in cell division, which maintains the mitotic state of cells.
Biochem/physiol Actions: RO-3306 is a selective ATP-competitive inhibitor of CDK1.
Biochem/physiol Actions: RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.
Features and Benefits: This compound is featured on the CDKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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