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Valspodar

SIGMA/SML0572 - ≥98% (HPLC)

Synonym: 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D; Amdray; PSC833; [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

CAS Number: 121584-18-7
Empirical Formula (Hill Notation): C63H111N11O12
Molecular Weight: 1214.62
MDL Number: MFCD00907207
Linear Formula: C63H111N11O12
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0572-5MG 5 mg
 $209.00
1/EA		 Add To Favorites
45-SML0572-25MG 25 mg
 $817.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0572-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1
InChI key YJDYDFNKCBANTM-QCWCSKBGSA-N
Quality Level 100 
shipped in wet ice
SMILES string N1([C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C1=O)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)C(=O)[C@@H](CC=CC)C)C)C(C)C)C
storage condition desiccated
storage temp. −20°C
Application: Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.
Biochem/physiol Actions: Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor.
Biochem/physiol Actions: Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12161501

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