Cucurbitacin E
SIGMA/SML0577 - ≥95% (HPLC)
Synonym: α-Elaterin; α-Elaterine
CAS Number: 18444-66-1
Empirical Formula (Hill Notation): C32H44O8
Molecular Weight: 556.69
Linear Formula: C32H44O8
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C32H44O8/c1-17(33)40-2 |
| InChI key | NDYMQXYDSVBNLL-MUYMLXPFSA |
| optical activity | [α]/D -60 to -75°, c = 0.7 (CDCl3) |
| Quality Level | 100  |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation. |
| Biochem/physiol Actions: | Cucurbitacin E is a potent inhibitor of actin depolymerization. |
| Biochem/physiol Actions: | Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |