EVP4593

SIGMA/SML0579 - ≥98% (HPLC)

Synonym: 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine; N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ

CAS Number: 545380-34-5
Empirical Formula (Hill Notation): C₂₂H₂₀N₄O
Molecular Weight: 356.42
MDL Number: MFCD06411436
Linear Formula: C₂₂H₂₀N₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0579-5MG	5 mg	$176.00 1/EA	Add To Favorites
45-SML0579-25MG	25 mg	$707.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI key	IBAKVEUZKHOWNG-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
solubility	DMSO: 15 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Biochem/physiol Actions:	EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC).
Biochem/physiol Actions:	EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.
Features and Benefits:	This compound is featured on the Calcium Channels , Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes:	Air sensitive
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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