Hispidulin

SIGMA/SML0582 - ≥98% (HPLC)

Synonym: 4′,5,7-Trihydroxy-6-methoxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 6-Methoxyapigenin; 6-Methylscutellarein; Dinatin; Salvitin; Scutellarein 6-methyl ether

CAS Number: 1447-88-7
Empirical Formula (Hill Notation): C₁₆H₁₂ O₆
Molecular Weight: 300.26
MDL Number: MFCD00143504
Linear Formula: C₁₆H₁₂ O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0582-5MG	5 mg	$154.00 1/EA	Add To Favorites
45-SML0582-25MG	25 mg	$599.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
InChI key	IHFBPDAQLQOCBX-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1
solubility	DMSO: 20 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Application:	Hispidulin has been used as a calibration standard: • in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids • in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis • in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
Biochem/physiol Actions:	Hispidulin also exhibits antiosteoporotic anti-atheromatous, antispasmodic and anticancer functionality. It exhibits inhibition on α-glucosidase enzymatic activity. Hispidulin inhibits platelet aggregation and is more effective than theophylline. It also acts as a modulator of the γ-aminobutyric acid receptor (GABA) and blocks the release of glutamate synaptosomes associated with cortical neurons.
Biochem/physiol Actions:	Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity.
Biochem/physiol Actions:	Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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