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Ferrostatin-1

SIGMA/SML0583 - ≥95% (HPLC)

Synonym: 3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;

CAS Number: 347174-05-4
Empirical Formula (Hill Notation): C15H22N2O2
Molecular Weight: 262.35
Linear Formula: C15H22N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0583-5MG 5 mg
 $87.80
1/EA		 Add To Favorites
45-SML0583-25MG 25 mg
 $357.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0583-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0583-5MG

 

assay ≥95% (HPLC)
color , faint purple to brown
form powder
InChI 1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChI key UJHBVMHOBZBWMX-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.
Biochem/physiol Actions: Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.
Biochem/physiol Actions: Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Biochem/physiol Actions: Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington’s disease and also prevents neurotoxicity induced by glutamate in cellular models.
Packaging: 5, 25 mg in glass bottle
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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