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Piclamilast

SIGMA/SML0585 - ≥98% (HPLC)

Synonym: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-benzamide; N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide; RP 73-401; RP 73401; RPR 73401

CAS Number: 144035-83-6
Empirical Formula (Hill Notation): C18H18Cl2N2O3
Molecular Weight: 381.25
Linear Formula: C18H18Cl2N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0585-5MG 5 mg
 $120.00
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45-SML0585-25MG 25 mg
 $465.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
InChI key RRRUXBQSQLKHEL-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1cncc(c1NC(=O)c2cc(c(cc2)OC)OC3CCCC3)Cl
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: Piclamilasthas been used as a phosphodiesterase-4 (PDE4) inhibitor to treat cultures at the indicated time points after blast exposure.
Biochem/physiol Actions: Piclamilast is a potent and selective cyclic AMP phosphodiesterase-4 inhibitor that exhibits equal, high affinity for both the PDE4 high- and low-affinity rolipram binding states (HARBS and LARBS). Recent studies shown that piclamilast inhibits Trypanosoma brucei PDEB1 (TbrPDEB1) and TbrPDEB2.
Biochem/physiol Actions: Piclamilast is a potent and selective cyclic AMP phosphodiesterase-4 inhibitor.
Biochem/physiol Actions: Piclamilast is also known as N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Piclamilast regulates the cAMP (cyclic adenosine monophosphate) signaling pathway. It increases the retinoid-dependent transactivation and the degradation of retinoic acid receptor α (RARα).
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Phosphodiesterases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41106305

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