Lomeguatrib

SIGMA/SML0586 - ≥98% (HPLC)

Synonym: 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine; O6-(4-bromothenyl)guanine

CAS Number: 192441-08-0
Empirical Formula (Hill Notation): C₁₀H₈BrN₅OS
Molecular Weight: 326.17
MDL Number: MFCD23703756
Linear Formula: C₁₀H₈BrN₅OS
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0586-5MG	5 mg	$120.00 1/EA	Add To Favorites
45-SML0586-25MG	25 mg	$315.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChI key	JUJPKFNFCWJBCX-UHFFFAOYSA-N
Quality Level	100
SMILES string	Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
solubility	DMSO: 10 mg/mL, clear
storage temp.	room temp

Biochem/physiol Actions:	Lomeguatrib is a highly potent inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein which can confer resistance to some cancer chemotherapeutics, in particular the DNA alkylating agents such as Temozolomide, DTIC, Carmustine, etc. Lomeguatrib is a highly potent inactivator of MGMT and can be used to further investigate mechanisms of resistance. It is a potent irreversible inactivator of all mammalian O6-alkylguanine-DNA-alkyltransferases, so far tested with nanomolar activity in vitro and in vivo.
Biochem/physiol Actions:	Lomeguatrib is a highly potent irreversible inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT).
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

To Order From a Quote