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Chlorthalidone

SIGMA/SML0591 - ≥98% (HPLC)

Synonym: 2-Chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide; 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; Chlortalidone

CAS Number: 77-36-1
Empirical Formula (Hill Notation): C14H11ClN2O4S
Molecular Weight: 338.77
EC Number: 201-022-5
Linear Formula: C14H11ClN2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0591-5MG 5 mg
 $70.00
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45-SML0591-25MG 25 mg
 $273.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChI key JIVPVXMEBJLZRO-UHFFFAOYSA-N
Quality Level 100 
SMILES string [S](=O)(=O)(N)c1c(ccc(c1)C2(NC(=O)c3c2cccc3)O)Cl
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Chlorthalidone is a thiazide-like diuretic, an inhibitor of the Na+-Cl- cotransporter.
Biochem/physiol Actions: Chlorthalidone is a thiazide-like diuretic, an inhibitor of the Na+-Cl- cotransporter. Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium increasing the delivery of sodium to the distal renal tubule and indirectly increasing potassium excretion via the sodium-potassium exchange mechanism. Chlorthalidone also promotes Ca++ reabsorption by an unknown mechanism. Several recent comparison studies inidcate that chlorthalidone may be a better drug in preventing cardiovascular events than hydrochlorothiazide.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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