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Strontium ranelate

SIGMA/SML0596 - ≥98% (HPLC)

Synonym: 2-[N,N-Di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid strontium salt; 5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid, strontium salt; Distrontium renelate; Ranelic acid strontium salt

CAS Number: 135459-87-9
Empirical Formula (Hill Notation): C12H6N2O8SSr2
Molecular Weight: 513.49
Linear Formula: C12H6N2O8SSr2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0596-10MG 10 mg
 $65.30
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45-SML0596-50MG 50 mg
 $255.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
InChI key XXUZFRDUEGQHOV-UHFFFAOYSA-J
Quality Level 100 
SMILES string [Sr+2].[Sr+2].[s]1c(c(c(c1C(=O)[O-])CC(=O)[O-])C#N)N(CC(=O)[O-])CC(=O)[O-]
solubility H2O: 1 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: Strontium ranelate is a dual action bone agent (DABA). It inhibits bone resorption and stimulates bone formation, inhibiting osteoclast differentiation while activating gene expression in osteoblasts. While its exact mechanism of action is unknown, one hypothesis is that both anabolic and anti-catabolic activities may involve antagonizing nuclear factor-KB (NF-KB) activation in bone cells. Strontium ranelate has been shown to inhibit the receptor activator of NF-KB ligand (RANKL)-induced nuclear translocation of NF-KB and activator protein-1. Strontium ranelate has been used clinically for the treatment of osteoporosis and a recent multinational study indicates the drug can also be used to treat osteoarthritis.
Biochem/physiol Actions: Strontium ranelate is a dual action bone agent (DABA); inhibitor of bone resorption and stimulator of bone formation.
Features and Benefits: This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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