Daurisoline

SIGMA/SML0597 - ≥98% (HPLC)

Synonym: (-)-Daurisoline; (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol; (R,R)-Daurisoline; O7-Demethyldauricine

CAS Number: 70553-76-3
Empirical Formula (Hill Notation): C₃₇H₄₂N₂O₆
Molecular Weight: 610.74
Linear Formula: C₃₇H₄₂N₂O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0597-5MG	5 mg	$101.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChI key	BURJAQFYNVMZDV-FIRIVFDPSA-N
Quality Level	100
SMILES string	N1([C@@H](c6c(cc(c(c6)OC)OC)CC1)Cc2ccc(cc2)Oc3c(ccc(c3)C[C@H]4N(CCc5c4cc(c(c5)OC)O)C)O)C
solubility	DMSO: 15 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Daurisoline alkaloid isolated from the rhizomes of Menispermum dauricum that exhibit varies pharmacological activities including antiplatelet aggregation, anti-inflammatory, neuron-protective properties, and antiarrhythmic effect. It appears that antiarrhythmic effect of daurisoline is maintained through blockade of hERG channels.
Biochem/physiol Actions:	Daurisoline is antiarrythmic, anti-inflammatory, neuron-protective; and blocks hERG channels.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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