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BPTES

SIGMA/SML0601 - ≥95% (HPLC)

Synonym: Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide

CAS Number: 314045-39-1
Empirical Formula (Hill Notation): C24H24N6O2S3
Molecular Weight: 524.68
MDL Number: MFCD01079848
Linear Formula: C24H24N6O2S3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0601-5MG 5 mg
 $146.00
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45-SML0601-25MG 25 mg
 $573.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0601-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0601-5MG

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)
InChI key MDJIPXYRSZHCFS-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.
Biochem/physiol Actions: BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. Glutaminase converts glutamine to glutamate, which is an important excitatory neurotransmitter in brain and can be further oxidized to α-ketoglutarate to feed the tricarboxylic acid (TCA) cycle and to glutathione, which is important for controlling the level of reactive oxygen species (ROS), particularly important for cancer cell growth. BPTES was found to slow growth of glioma cells. BPTES is a noncompetitive inhibitor with a Ki of 3 μM.
Biochem/physiol Actions: BPTES is a selective inhibitor of Glutaminase GLS1.
Biochem/physiol Actions: Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.
Packaging: 5, 25 mg in glass bottle
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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