Lixivaptan

SIGMA/SML0603 - ≥96% (HPLC)

Synonym: N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide; VPA 985; WAY-VPA 985

CAS Number: 168079-32-1
Empirical Formula (Hill Notation): C₂₇H₂₁ClFN₃O₂
Molecular Weight: 473.93
Linear Formula: C₂₇H₂₁ClFN₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0603-5MG	5 mg	$92.10 1/EA	Add To Favorites
45-SML0603-25MG	25 mg	$359.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥96% (HPLC)
color	white to beige
description	4% w/w in ethyl acetate
form	powder
InChI	1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
InChI key	PPHTXRNHTVLQED-UHFFFAOYSA-N
Quality Level	100
SMILES string	Fc1cc(c(cc1)C)C(=O)Nc2cc(c(cc2)C(=O)N3Cc4[n](ccc4)Cc5c3cccc5)Cl
solubility	DMSO: 20 mg/mL, clear
storage temp.	room temp

Biochem/physiol Actions:	Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.
Biochem/physiol Actions:	Lixivaptan is an arginine vasopressin (AVP) V2-receptor antagonist.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥96% (HPLC)
Storage Temp.	room temp
UNSPSC	51111800

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