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Perifosine

SIGMA/SML0612 - ≥98% (HPLC)

Synonym: 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium inner salt; KRX-0401; Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

CAS Number: 157716-52-4
Empirical Formula (Hill Notation): C25H52NO4P
Molecular Weight: 461.66
Linear Formula: C25H52NO4P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0612-10MG 10 mg
 $148.00
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45-SML0612-50MG 50 mg
 $599.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3
InChI key SZFPYBIJACMNJV-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string [P](=O)([O-])(OC1CC[N+](CC1)(C)C)OCCCCCCCCCCCCCCCCCC
solubility H2O: 10 mg/mL, clear
storage temp. −20°C
Application: Perifosine has been used as an alkyl phospholipid AKT inhibitor.
Biochem/physiol Actions: Perifosine (KRX-0401) is a selective bioavailable alkylphospholipid inhibitor of protein kinase B/Akt (PKB/Akt) with anti-proliferative activity.
Biochem/physiol Actions: Perifosine (KRX-0401) is a selective bioavailable alkylphospholipid inhibitor of protein kinase B/Akt (PKB/Akt) with anti-proliferative activity. Perifosine acts on cell membranes, selectively targeting proliferating cells, inducing growth arrest and apoptosis.
Biochem/physiol Actions: Perifosine (octadecyl-(1,1-dimethyl-4-piperidylio)) is an antitumor compound. It acts at lipid rafts and stops lysosomal accumulation and mTORC1 (mammalian target of rapamycin complex 1) signaling. This drug exhibits significant antiproliferative activity in vitro and in vivo in various human cancer model systems.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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