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Rofecoxib

SIGMA/SML0613 - ≥98% (HPLC)

Synonym: 4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone

CAS Number: 162011-90-7
Empirical Formula (Hill Notation): C17H14O4S
Molecular Weight: 314.36
Linear Formula: C17H14O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0613-10MG 10 mg
 $91.90
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45-SML0613-50MG 50 mg
 $392.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChI key RZJQGNCSTQAWON-UHFFFAOYSA-N
Quality Level 100 
SMILES string [S](=O)(=O)(C)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Rofecoxib has been used in high performance bioaffinity chromatography.
Biochem/physiol Actions: Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with >800-fold COX-2 selectivity in CHO cells expressing human COX-1 and COX-2.
Biochem/physiol Actions: Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor.
Biochem/physiol Actions: Rofecoxib is derived from furanone and has the ability to cross human placenta. Along with anti-inflammatory action, it possesses analgesic and antipyretic properties. Cytosolic hepatic enzymes are responsible for the metabolism of rofecoxib. It is known to cause oligohydramnios and ductus arteriosus constrictions. Rofecoxib inhibits the action of CYP1A2 (cytochrome P450 family 1 subfamily A member 2). It might be associated with aseptic meningitis. Rofecoxib is known to ameliorate the risk of colorectal adenoma, but might contribute to toxicity.
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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