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AF-DX 384 Free Base

SIGMA/SML0620 - ≥98% (HPLC)

Synonym: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

CAS Number: 118290-26-9
Empirical Formula (Hill Notation): C27H38N6O2
Molecular Weight: 478.63
Linear Formula: C27H38N6O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0620-5MG 5 mg
 $91.80
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)
InChI key MZDYABXXPZNUCT-UHFFFAOYSA-N
Quality Level 100 
SMILES string N4(C(CCCC4)CN(CCC)CCC)CCNC(=O)[n]1c2ncccc2[nH][c](c3c1cccc3)=O
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. room temp
Biochem/physiol Actions: AF-DX 384 Free Base is a muscarinic M2/M4 receptor selective antagonist.
Biochem/physiol Actions: AF-DX 384 Free Base is a potent muscarinic M2/M4 receptor selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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