AC253 trifluoroacetate salt
SIGMA/SML0625 - ≥95% (HPLC)
Synonym: Amylin Antagonist AC253
Empirical Formula (Hill Notation): C122H196N40O39 · xC2HF3O2
Molecular Weight: 2847.11 (free base basis)
Linear Formula: C122H196N40O39 · xC2HF3O2
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| color | white to off-white |
| form | powder |
| Quality Level | 100  |
| shipped in | wet ice |
| storage temp. | −20°C |
| Amino Acid Sequence: | Ac-Leu-Gly-Arg-Leu-Ser-Gl |
| Biochem/physiol Actions: | AC253 is an antagonist of Amylin, one of the peptides in the Calcitonin-gene related peptide (CGRP) family. In recent studies. AC253 restored memories in brain cells taken from animals used as models of Alzheimer′s disease. Application of AC253 significantly enhanced long-term potentiation (LTP) when given to 6- to 12-month-old TgCRND8 mice that normally show blunted LTP. In other studies, AC25 neutralized the depressant effects of Aβ(1-42) on hippocampal LTP without affecting baseline transmission or LTP on its own. |
| Biochem/physiol Actions: | AC253 is an antagonist of Amylin. |
| Features and Benefits: | This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 1 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |