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ML-SA1

SIGMA/SML0627 - ≥95% (HPLC)

Synonym: 1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline; 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione; Mucolipin Synthetic Agonist 1

CAS Number: 332382-54-4
Empirical Formula (Hill Notation): C22H22N2O3
Molecular Weight: 362.42
Linear Formula: C22H22N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0627-25MG 25 mg
 $171.00
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assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChI key KDDHBJICVBONAX-UHFFFAOYSA-N
Quality Level 100 
SMILES string N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.
Biochem/physiol Actions: ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.
Biochem/physiol Actions: ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3.
Packaging: 25 mg in glass bottle
Hazard Codes T
Risk Statements 25-50/53
Safety Statements 60-61
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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