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AZD6765 dihydrochloride

SIGMA/SML0635 - ≥97% (HPLC)

Synonym: (αS)-α-Phenyl-2-pyridineethanamine dihydrochloride; AR-R 15896 dihydrochloride; FPL 15896 dihydrochloride; Lanicemine dihydrochloride

CAS Number: 153322-06-6
Empirical Formula (Hill Notation): C13H14N2 · 2HCl
Molecular Weight: 271.19
Linear Formula: C13H14N2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0635-5MG 5 mg
 $83.30
1/EA		 Add To Favorites
45-SML0635-25MG 25 mg
 $323.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
InChI key KHJHFYAGQZYCLC-GXKRWWSZSA-N
optical activity [α]/D +77 to +90°, c = 1 in methanol
Quality Level 100 
SMILES string [Cl-].[Cl-].[N+H3][C@@H](Cc2[n+H]cccc2)c1ccccc1
solubility H2O: 20 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: AZD6765 dihydrochloride has been used as an antidepressant to improve behavior and metabolic measures in chronic unpredictable mild stress (CUMS).
Biochem/physiol Actions: AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant.
Biochem/physiol Actions: AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC50 value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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