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GMX1778

SIGMA/SML0646 - ≥98% (HPLC)

Synonym: CHS 828; CHS-828; GMX 1778; N-[6-(4-Chlorophenoxy)hexyl]-N′-cyano-N′′-4-pyridinyl-guanidine

CAS Number: 200484-11-3
Empirical Formula (Hill Notation): C19H22ClN5O
Molecular Weight: 371.86
Linear Formula: C19H22ClN5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0646-5MG 5 mg
 $113.00
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45-SML0646-25MG 25 mg
 $437.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
InChI key BOIPLTNGIAPDBY-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1ccc(cc1)OCCCCCCNC(=NC#N)Nc2ccncc2
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.
Biochem/physiol Actions: GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells.
Biochem/physiol Actions: GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.
Biochem/physiol Actions: GMX1778 is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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