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Deshydroxy LY-411575

SIGMA/SML0649 - ≥98% (HPLC)

Synonym: γ-Secretase inhibitor XX; (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide; DBZ; Dibenzazepine; GSI-XX; N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide; YO-01027

CAS Number: 209984-56-5
Empirical Formula (Hill Notation): C26H23F2N3O3
Molecular Weight: 463.48
Linear Formula: C26H23F2N3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0649-5MG 5 mg
 $130.00
1/EA		 Add To Favorites
45-SML0649-25MG 25 mg
 $532.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1
InChI key QSHGISMANBKLQL-OWJWWREXSA-N
optical activity [α]/D -128.0 to -154.0°-0.25 in methanol
Quality Level 100 
SMILES string Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)N[C@H]2c3c(cccc3)c4c(cccc4)N(C2=O)C)F
solubility DMSO: 15 mg/mL, clear
storage temp. −20°C
Application: Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.
Biochem/physiol Actions: Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing.
Biochem/physiol Actions: Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells.
Biochem/physiol Actions: LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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