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Capecitabine

SIGMA/SML0653 - ≥98% (HPLC)

Synonym: 5′-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine; Ro-9-1978

CAS Number: 154361-50-9
Empirical Formula (Hill Notation): C15H22FN3O6
Molecular Weight: 359.35
MDL Number: MFCD00930626
Linear Formula: C15H22FN3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0653-10MG 10 mg
 $61.10
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45-SML0653-50MG 50 mg
 $206.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
InChI key GAGWJHPBXLXJQN-UORFTKCHSA-N
optical activity [α]/D +80 to +100°, c = 0.5 in methanol
Quality Level 100 
SMILES string O[C@H]1[C@@H](O)[C@H](N2C(N=C(NC(OCCCCC)=O)C(F)=C2)=O)O[C@@H]1C
solubility H2O: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Capecitabine has been used:

• in combination with gemcitabine to achieve glutamine deprivation by enhancing the sensitivity of expression in pancreatic ductal adenocarcinoma (PDAC) cells to inhibitors of glutamine metabolism and study its effect on PDAC cell survival
• to study the drug metabolic function in a two-organ microfluidic system
• as an anti-cancer agent to study its cytotoxic activity alone or in combination with B87 on cancer cells
Biochem/physiol Actions: Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site.
Biochem/physiol Actions: Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5′-Deoxy-5-fluorocytidine (5′-DFCR) and 5′-Deoxy-5-fluorouridine (5′-DFUR), to form 5-fluorouracil.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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