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Entacapone

SIGMA/SML0654 - ≥98% (HPLC)

Synonym: 2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide

CAS Number: 130929-57-6
Empirical Formula (Hill Notation): C14H15N3O5
Molecular Weight: 305.29
Linear Formula: C14H15N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0654-10MG 10 mg
 $79.60
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45-SML0654-50MG 50 mg
 $264.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
InChI key JRURYQJSLYLRLN-BJMVGYQFSA-N
Quality Level 100 
SMILES string [N+](=O)([O-])c1c(c(cc(c1)C=C(C(=O)N(CC)CC)/C#N)O)O
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Application: Entacapone has been used in high-performance bioaffinity chromatography.
Biochem/physiol Actions: Entacapone acts predominantly in the intestine. It increases the bioavailability of levodopa. Levodopa is known to be associated with many complications such as motor fluctuations. COMT inhibitors have been used to overcome these adverse effects of levodopa by reducing its metabolism. Entacapone exhibits its inhibition action on COMT in the peripheral nervous system.
Biochem/physiol Actions: Entacapone is a catechol-O-methyl transferase (COMT) inhibitor. Antiparkinson; anti-Dyskinesia.
Biochem/physiol Actions: Entacapone is a catechol-O-methyl transferase (COMT) inhibitor. Used in treatment of Parkinson′s disease, entacapone is administered with L-DOPA to inihibit COMT from converting L-DOPA into a compound that cannot cross the blood brain barrier.
Features and Benefits: This compound is featured on the Dopamine and Norepinephrine Metabolism  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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