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GSK2578215A

SIGMA/SML0660 - ≥98% (HPLC)

Synonym: 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-benzamide

CAS Number: 1285515-21-0
Empirical Formula (Hill Notation): C24H18FN3O2
Molecular Weight: 399.42
Linear Formula: C24H18FN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0660-5MG 5 mg
 $130.00
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45-SML0660-25MG 25 mg
 $532.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
InChI key WCIGMFCFPXZRMQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1nccc(c1)c2cc(c(cc2)OCc4ccccc4)C(=O)Nc3cnccc3
solubility DMSO: 15 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: GSK2578215A is a potent inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson’s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. GSK2578215A inhibited both wild-type and G2019S mutant LRRK2 kinase activity with IC50s of 10.9 and 8.9 nM respectively. It has good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.
Biochem/physiol Actions: GSK2578215A is a potent inhibitor of leucine-rich repeat kinase-2 (LRRK2).
Biochem/physiol Actions: GSK2578215A stimulates mitochondrial fragmentation, autophagy and mitophagy.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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