UNC1215

SIGMA/SML0662 - ≥98% (HPLC)

Synonym: [2-Phenylamino-4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

CAS Number: 1415800-43-9
Empirical Formula (Hill Notation): C₃₂H₄₃N₅O₂
Molecular Weight: 529.72
MDL Number: MFCD22683289
Linear Formula: C₃₂H₄₃N₅O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0662-5MG	5 mg	$120.00 1/EA	Add To Favorites
45-SML0662-25MG	25 mg	$386.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChI key	PQOOIERVZAXHBP-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(N1CCC(N2CCCC2)CC1)C3=CC(NC4=CC=CC=C4)=C(C(N5CCC(N6CCCC6)CC5)=O)C=C3
solubility	DMSO: 5 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity.
Biochem/physiol Actions:	UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins that are important epigenetic regulators that “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions that regulate gene expression. UNC1215 has an IC₅₀ of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. For full characterization details, please visit the UNC1215 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	UNC1215 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC
Other Notes:	UNC1215 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC1215 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12171501

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