LM11A-31 dihydrochloride

SIGMA/SML0664 - ≥95% (HPLC)

Synonym: 2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride

CAS Number: 1214672-15-7
Empirical Formula (Hill Notation): C₁₂H₂₅N₃O₂ · 2HCl
Molecular Weight: 316.27
MDL Number: MFCD11505486
Linear Formula: C₁₂H₂₅N₃O₂ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0664-5MG	5 mg	$73.20 1/EA	Add To Favorites
45-SML0664-25MG	25 mg	$284.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	colorless to yellow
form	oil
InChI	1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
InChI key	LLIHJRRZJDEKLB-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
storage condition	desiccated
storage temp.	2-8°C

Application:	LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.
Biochem/physiol Actions:	LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.
Biochem/physiol Actions:	LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H315 - H319 - H335 - H410
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi,N
Risk Statements	36/37/38-50
Safety Statements	26-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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