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PF-429242 dihydrochloride

SIGMA/SML0667 - ≥98% (HPLC)

Synonym: 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride; PF 429242 dihydrochloride

CAS Number: 947303-87-9 (free base)
Empirical Formula (Hill Notation): C25H35N3O2 · 2HCl
Molecular Weight: 482.49
Linear Formula: C25H35N3O2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0667-5MG 5 mg
 $167.00
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45-SML0667-25MG 25 mg
 $665.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H35N3O2/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3/h6-13,23,26H,4-5,14-19H2,1-3H3/t23-/m1/s1
InChI key XKPJTOHUPQWSOJ-HSZRJFAPSA-N
Quality Level 100 
SMILES string N1C[C@@H](CC1)N(CCc3c(cccc3)OC)C(=O)c2ccc(cc2)CN(CC)CC
solubility H2O: 15 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: PF-429242 dihydrochloride has been used as an inhibitor of sterol regulatory element-binding protein (SREBP).
Biochem/physiol Actions: PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV.
Biochem/physiol Actions: PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease).
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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