Calhex 231 hydrochloride
SIGMA/SML0668 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 652973-93-8 (free base)
Empirical Formula (Hill Notation): C25H27ClN2O · HCl
Molecular Weight: 443.41
Linear Formula: C25H27ClN2O · HCl
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 15 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | Calhex 231 hydrochloride has been used: • as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats • to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs) • to test its effect on acoustic response bias in zebrafish • in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 ) |
| Biochem/physiol Actions: | Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. |
| Biochem/physiol Actions: | Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |