Nitecapone

SIGMA/SML0671 - ≥98% (HPLC)

Synonym: 3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione; OR-462

CAS Number: 116313-94-1
Empirical Formula (Hill Notation): C₁₂H₁₁NO₆
Molecular Weight: 265.22
Linear Formula: C₁₂H₁₁NO₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0671-5MG	5 mg	$58.20 1/EA	Add To Favorites
45-SML0671-25MG	25 mg	$332.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3
InChI key	UPMRZALMHVUCIN-UHFFFAOYSA-N
Quality Level	100
SMILES string	[N+](=O)([O-])c1c(c(cc(c1)C=C(C(=O)C)C(=O)C)O)O
solubility	DMSO: 15 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT).
Biochem/physiol Actions:	Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.
Features and Benefits:	This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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