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CYM-5541

SIGMA/SML0680 - ≥98% (HPLC)

Synonym: CYM5541; ML249; N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide; N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

CAS Number: 945128-26-7
Empirical Formula (Hill Notation): C19H28N2O2
Molecular Weight: 316.44
Linear Formula: C19H28N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0680-5MG 5 mg
 $115.00
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45-SML0680-25MG 25 mg
 $361.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
InChI key NDKGACIWVAOUQH-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype.
Biochem/physiol Actions: CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
Features and Benefits: This compound is featured on the Lysophospholipid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352211

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