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Febrifugine dihydrochloride

SIGMA/SML0681 - ≥95% (HPLC)

Synonym: 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride

CAS Number: 32434-42-7
Empirical Formula (Hill Notation): C16H19N3O3 · 2HCl
Molecular Weight: 374.26
Linear Formula: C16H19N3O3 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0681-5MG 5 mg
 $197.00
1/EA		 Add To Favorites
45-SML0681-25MG 25 mg
 $789.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color off-white to gray-brown
form powder
InChI 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
InChI key SNTOTCUGCWLHEZ-KKJWGQAZSA-N
optical activity [α]/D 10 to 15°, c = 1 in H2O
Quality Level 100 
SMILES string O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
solubility H2O: 15 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Biochem/physiol Actions: Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).
Biochem/physiol Actions: Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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