JNJ-40418677
SIGMA/SML0683 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 1146594-87-7
Empirical Formula (Hill Notation): C26H22F6O2
Molecular Weight: 480.44
Linear Formula: C26H22F6O2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| originator | Johnson & Johnson |
| Quality Level | 100  |
| relevant disease(s) | Alzheimer′s disease |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38. |
| Biochem/physiol Actions: | JNJ-40418677 is a γ-secretase modulator. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 - H413 |
| Precautionary statements | P273 - P301 + P310 + P330 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |