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SF1670

SIGMA/SML0684 - ≥98% (HPLC)

Synonym: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide; N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide

CAS Number: 345630-40-2
Empirical Formula (Hill Notation): C19H17NO3
Molecular Weight: 307.34
Linear Formula: C19H17NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0684-5MG 5 mg
 $268.00
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assay ≥98% (HPLC)
color , light pink to red to very dark purple
form powder
InChI 1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChI key VZQDDSYKVYARDW-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(c1cc2c(cc1)c3c(cccc3)C(=O)C2=O)C(=O)C(C)(C)C
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: SF1670 has been used:
• To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
• To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
• To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.
Biochem/physiol Actions: PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
Biochem/physiol Actions: SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.
Biochem/physiol Actions: SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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