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LY-333531 hydrochloride

SIGMA/SML0693 - ≥98% (HPLC)

Synonym: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride; Ruboxistaurin

CAS Number: 169939-93-9
Empirical Formula (Hill Notation): C28H28N4O3 · HCl
Molecular Weight: 505.01
Linear Formula: C28H28N4O3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0693-1MG 1 mg
 $167.00
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assay ≥98% (HPLC)
color orange-red
form powder
InChI 1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
InChI key NYQIEYDJYFVLPO-FERBBOLQSA-N
Quality Level 100 
SMILES string Cl.[n]21c3c(c(c2)C4=C(c5c6c([n](c5)CC[C@H](OCC1)CN(C)C)cccc6)C(=O)NC4=O)cccc3
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
  protect from light
storage temp. −20°C
Application: LY-333531 hydrochloride/ruboxistaurin has been used as a PKCB blocker to compare phosphopeptides derived from stimulated wild-type cells to phosphopeptides derived from either PKCB knockout cells or wild-type cells.
Biochem/physiol Actions: LY333531 is a potent inhibitor of protein kinase Cβ (PKCβ; 4.7 and 5.9 nM IC50 values for PKCβ1 and PKCβ2, respectively). PKCβ isoforms are overexpressed in states of oxidative stress, especially in association with diabetes. In diabetic rats, LY333531 improves blood flow and leukocyte entrapment in the retina, and protects against myocardial hypertrophy and cardiac dysfunction.
Biochem/physiol Actions: LY333531 is a potent, specific inhibitor of PKCβ.
Features and Benefits: This compound is featured on the PKC  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: LY-333531 hydrochloride is also known as ruboxistaurin.
Other Notes: Light sensitive
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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