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BX-795 hydrochloride

SIGMA/SML0694 - ≥98% (HPLC)

Synonym: N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-Pyrrolidinecarboxamide hydrochloride

CAS Number: 702675-74-9 (free base)
Empirical Formula (Hill Notation): C23H26IN7O2S · xHCl
Molecular Weight: 591.47 (free base basis)
Linear Formula: C23H26IN7O2S · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0694-5MG 5 mg
 $121.00
1/EA		 Add To Favorites
45-SML0694-25MG 25 mg
 $468.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
InChI key VAVXGGRQQJZYBL-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c4cccs4
solubility DMSO: 15 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: BX-795 hydrochloride has been used to study the effect of kinase inhibition on human endogenous retroviruses (HERVs) transcription activation.
Biochem/physiol Actions: BX-795 competes for the ATP (adenosine triphosphate) binding pocket of 3-phosphoinositide-dependent kinase-1 (PDK1) with its substrate ATP. In vitro assays reveal that BX-795 might inhibit Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1).
Biochem/physiol Actions: BX-795 is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKK epsilon)′
Biochem/physiol Actions: BX-795 was initially characterized as a potent inhbitor of 3-phosphoinositide-dependent kinase-1. Additional studies with BX-795 have shown that the molecule is also a potent dual inhibitor of IKKe and TBK1 which are known to regulate the expression of interferons via the phosphorylation of interferon regulatory factor 3 (IRF3).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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