FTY720
SIGMA/SML0700 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 162359-56-0
Empirical Formula (Hill Notation): C19H33NO2 · HCl
Molecular Weight: 343.93
Linear Formula: C19H33NO2 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0700-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0700-5MG
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C19H33NO2.ClH/c1-2-3-4 |
| InChI key | SWZTYAVBMYWFGS-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.NC(CO)(CO)CCc1ccc(cc1) |
| solubility | water: 10 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | FTY720 has been used as an immunomodulator and is used to investigate its effect on in vitro gastrulation model of P19C5 stem cells. It is also used to determine its efficacy in prolonging the survival corneal transplantation. FTY720 has been used to study its effect on the proliferation and differentiation of cultured embryonic hippocampal neural stem cells (NSCs) using the 5-bromo-2-deoxyuridine incorporation assay, the neurosphere formation assay and western blot analysis. |
| Biochem/physiol Actions: | FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory. |
| Biochem/physiol Actions: | FTY720, an immunomodulating drug, acts as a sphingosine 1-phosphate (S1P) receptor modulator. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260 - P314 - P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-52/53 |
| Safety Statements | 26-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352211 |